Rosa multiflora

Anti-inflammatory and analgesic effects of the ethanol extract of Rosa multiflora Thunb. hips.
J Ethnopharmacol. 2008 Jul 23; Zhang GQ, Huang XD, Wang H, Leung AK, Chan CL, Fong DW, Yu ZL. Research Division of Pharmacology, China Pharmaceutical University, Nanjing 210009, PR China.
This study aimed to assess the anti-inflammatory and analgesic effects of Fructus Rosae Multiflorae (hips of Rosa multiflora Thunb.). Rosa multiflora was extracted with 75% ethanol and the dried extract was administered intragastrically (i.g.) at 100, 200 and 400mg/kg. The anti-inflammatory effect was evaluated in four experimental animal models and analgesic effect in two animal models. Pretreatment with a single dose of Rosa multiflora extract produced significant dose-dependent anti-inflammatory effects on carrageenin-induced rat hind paw edema, xylene-induced mouse ear edema and acetic acid-induced mouse vascular permeation. In a 7-day study, daily administration of Rosa multiflora extract suppressed cotton pellet-induced rat granuloma formation. Pretreatment with a single dose of Rosa multiflora extract also produced dose-dependent anti-nociceptive effects in thermally- and chemically induced mouse pain models. In addition, a single dose of Rosa multiflora extract at 2.4g/kg body weight (equivalent to 87.6g of dried hips per kg body weight) produced no observable acute toxicity in mice within seven days. These results demonstrate that Rosa multiflora extract possesses anti-inflammatory and analgesic effects and has no obvious acute toxicity, which advanced our understanding of the folk use of Rosa multiflora extract in treating various inflammatory disorders.

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