Rhodiola imbricata root health benefit

Rhodiola imbricata is a medicinal plant, native to mountainous regions of Asia, parts of Europe, and the Arctic. Traditionally it is recommended to help combat fatigue and restore energy. It exhibits anti-stress, anti-cancer, and immune system effects.

A dose dependent adaptogenic and safety evaluation of Rhodiola imbricata Edgew, a high altitude rhizome.
Food Chem Toxicol. 2008 May; Gupta V, Saggu S, Tulsawani RK, Sawhney RC, Kumar R. Department of Biochemical Pharmacology, Defence Institute of Physiology and Allied Sciences (DIPAS), Timarpur, Delhi, India.
To examine the dose dependent adaptogenic activity aqueous extract of Rhodiola imbricata root was orally administered in rats at different doses, 30 min prior to cold (5 degrees C)-hypoxia (428 mm Hg)-restraint (C-H-R) exposure. The maximal effective adaptogenic dose of the extract was 100 mg/kg body weight. The acute and sub-acute toxicity of the extract was also studied in rats. No histopathological changes were observed in the vital organs studied of the treated animals. These results suggest that aqueous extract of R. imbricata root possess potent adaptogenic activity with no acute and sub-acute toxicity.

Mechanism of action of Rhodiola imbricata Edgew during exposure to cold, hypoxia and restraint (C-H-R) stress induced hypothermia and post stress recovery in rats.
Food Chem Toxicol. 2009 Feb 24. Gupta V, Lahiri SS, Sultana S, Kumar R. Department of Biochemical Pharmacology, Defence Institute of Physiology and Allied Sciences (DIPAS), Lucknow Road, Timarpur, Delhi 110 054, India.
Mechanism of rhodiola imbricata root extract adaptogenic activity was studied in rats. The rhodiola imbricata root extract was orally administered in rats 30 min prior to cold. Our results suggest that rrhodiola imbricata root extract treatment in rats shifted anaerobic metabolism to aerobic, during C-H-R exposure and post stress recovery.

supplement benefit side effect